Genome-wide interaction study of dust mite allergen on lung function in children with asthma.

ABSTRACT:

Background

Childhood asthma is likely the result of gene-by-environment (G × E) interactions. Dust mite is a known risk factor for asthma morbidity. Yet, there have been no genome-wide G × E studies of dust mite allergen on asthma-related phenotypes.

Objective

We sought to identify genetic variants whose effects on lung function in children with asthma are modified by the level of dust mite allergen exposure.

Methods

A genome-wide interaction analysis of dust mite allergen level and lung function was performed in a cohort of Puerto Rican children with asthma (Puerto Rico Genetics of Asthma and Lifestyle [PRGOAL]). Replication was attempted in 2 independent cohorts, the Childhood Asthma Management Program (CAMP) and the Genetics of Asthma in Costa Rica Study.

Result

SUBMITTER: Forno E 

PROVIDER: S-EPMC5544591 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature