Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
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ABSTRACT:
SUBMITTER: Kotenko SV
PROVIDER: S-EPMC26498 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Kotenko S V SV Saccani S S Izotova L S LS Mirochnitchenko O V OV Pestka S S
Proceedings of the National Academy of Sciences of the United States of America 20000201 4
We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retain ...[more]
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