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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).


ABSTRACT: We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retained two of four introns of the IL-10 gene, but the length of the introns was reduced. We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system.

SUBMITTER: Kotenko SV 

PROVIDER: S-EPMC26498 | biostudies-literature | 2000 Feb

REPOSITORIES: biostudies-literature

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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

Kotenko S V SV   Saccani S S   Izotova L S LS   Mirochnitchenko O V OV   Pestka S S  

Proceedings of the National Academy of Sciences of the United States of America 20000201 4


We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retain  ...[more]

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