Ontology highlight
ABSTRACT:
SUBMITTER: Flachsbart F
PROVIDER: S-EPMC2650329 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Flachsbart Friederike F Caliebe Amke A Kleindorp Rabea R Blanché Hélène H von Eller-Eberstein Huberta H Nikolaus Susanna S Schreiber Stefan S Nebel Almut A
Proceedings of the National Academy of Sciences of the United States of America 20090205 8
The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms. A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a discovery sample of long-lived men of Japanese ancestry [Willcox et al. (2008) Proc Natl Acad Sci USA 105:13987-13992]. However, this finding required replication in an independent ...[more]