Ontology highlight
ABSTRACT:
SUBMITTER: Lescai F
PROVIDER: S-EPMC2986679 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Lescai Francesco F Blanché Helene H Nebel Almut A Beekman Marian M Sahbatou Mourad M Flachsbart Friederike F Slagboom Eline E Schreiber Stefan S Sorbi Sandro S Passarino Giuseppe G Franceschi Claudio C
European journal of human genetics : EJHG 20090415 11
The 11p15.5 chromosomal region (2.8 Mb) is of particular interest as it encloses five genes (HRAS1, SIRT3, TH, INS and IGF2), the variability of which was found to be associated with life extension by association studies. Mostly important, the above genes are homologous of genes that modulate lifespan in model organisms. We scanned the area in four European sample groups for a total of 1321 centenarians and 1140 younger subjects, who shared with centenarians ethnicity and geographical origin, wi ...[more]