Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC2650370 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Liu Guofa G Li Weiquan W Wang Lei L Kar Amar A Guan Kun-Liang KL Rao Yi Y Wu Jane Y JY
Proceedings of the National Academy of Sciences of the United States of America 20090205 8
Down syndrome cell adhesion molecule (DSCAM) is required for axon guidance and dendrite arborization. How DSCAM functions in vertebrates is not well understood. Here we show that DSCAM is expressed on commissural axons and interacts with Netrin-1, a prototypical guidance cue for commissural axons. The knockdown of DSCAM by specific siRNA or blockage of DSCAM signaling by overexpression of a mutant lacking its intracellular domain inhibits netrin-induced axon outgrowth and commissural axon turnin ...[more]