Ontology highlight
ABSTRACT:
SUBMITTER: Wieland Brown LC
PROVIDER: S-EPMC2650375 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Wieland Brown Laura C LC Acker Michael G MG Clardy Jon J Walsh Christopher T CT Fischbach Michael A MA
Proceedings of the National Academy of Sciences of the United States of America 20090205 8
The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-terminal 14 residues of a 52-residue peptide precursor undergo 13 posttranslational modifications to give rise to thiocillin, making this antibiotic the most heavily posttranslationally-modified peptide known t ...[more]