Ontology highlight
ABSTRACT:
SUBMITTER: Poirel L
PROVIDER: S-EPMC2650541 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20081215 3
Chromosomally encoded ss-lactamases from the Burkholderia cepacia complex species (formerly Pseudomonas cepacia) were characterized. Cloning and sequencing identified an Ambler class A ss-lactamase (PenB) from B. cenocepacia. It shares 82% amino acid identity with the PenA ss-lactamases previously identified from B. multivorans 249. Its expression was dependent upon a LysR-type regulatory protein. Its narrow-spectrum hydrolysis activity mostly included penicillins but also included expanded-spec ...[more]