Ontology highlight
ABSTRACT:
SUBMITTER: Salter AB
PROVIDER: S-EPMC2651019 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Salter Alice B AB Meadows Sarah K SK Muramoto Garrett G GG Himburg Heather H Doan Phuong P Daher Pamela P Russell Lauren L Chen Benny B Chao Nelson J NJ Chute John P JP
Blood 20090113 9
Hematopoietic stem cells (HSCs) reside in association with bone marrow (BM) sinusoidal vessels in vivo, but the function of BM endothelial cells (ECs) in regulating hematopoiesis is unclear. We hypothesized that hematopoietic regeneration following injury is regulated by BM ECs. BALB/c mice were treated with total body irradiation (TBI) and then infused with C57Bl6-derived endothelial progenitor cells (EPCs) to augment endogenous BM EC activity. TBI caused pronounced disruption of the BM vascula ...[more]