Ontology highlight
ABSTRACT:
SUBMITTER: Halterman MW
PROVIDER: S-EPMC2652244 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Halterman Marc W MW De Jesus Christopher C Rempe David A DA Schor Nina F NF Federoff Howard J HJ
Molecular and cellular neurosciences 20080213 2
Understanding the mechanisms governing the switch between hypoxia-induced adaptive and pathological transcription may reveal novel therapeutic targets for stroke. Using an in vitro hypoxia model that temporally separates these divergent responses, we found apoptotic signaling was preceded by a decline in c/EBP-beta activity and was associated with markers of ER-stress including transient eIF2alpha phosphorylation, and the delayed induction of the bZIP proteins ATF4 and CHOP-10. Pretreatment with ...[more]