Ontology highlight
ABSTRACT:
SUBMITTER: Hartford CM
PROVIDER: S-EPMC2652364 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Hartford Christine M CM Duan Shiwei S Delaney Shannon M SM Mi Shuangli S Kistner Emily O EO Lamba Jatinder K JK Huang R Stephanie RS Dolan M Eileen ME
Blood 20081224 10
Cytarabine arabinoside (ara-C) is an antimetabolite used to treat hematologic malignancies. Resistance is a common reason for treatment failure with adverse side effects contributing to morbidity and mortality. Identification of genetic factors important in susceptibility to ara-C cytotoxicity may allow for individualization of treatment. We used an unbiased whole-genome approach using lymphoblastoid cell lines derived from persons of European (CEU) or African (YRI) ancestry to identify these ge ...[more]