Ontology highlight
ABSTRACT:
SUBMITTER: Jiang MX
PROVIDER: S-EPMC2652561 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20060501 11
Carbocyclic nucleosides are of considerable interest for the development of new therapeutic agents. A key reaction in the preparation of many such nucleoside analogues is dihydroxylation of appropriately substituted cyclopentenes. Although often considered a routine reaction, in this paper, we report the dramatic influence of substituents on the facial selectivity of dihydroxylations. The substituted cyclopentene substrates are derived from acylnitroso cycloaddition reactions of cyclopentadiene, ...[more]