Ontology highlight
ABSTRACT:
SUBMITTER: Yousfi T
PROVIDER: S-EPMC6274280 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20161201 12
The efficient organocatalytic synthesis of heterocyclic systems of biological relevance is a subject of growing interest. We have found that the pyrrolidine/benzoic acid-catalyzed reaction of α-substituted propenals such as methacrolein, 2-benzylpropenal and 2-(<i>n</i>-hexyl)propenal with activated hydrazines takes place in very good yields (83%-99.6%) under very mild conditions to afford 4-substituted pyrazolidin-3-ols (as diastereomer mixtures); subsequent oxidation with PCC affords the corre ...[more]