Ontology highlight
ABSTRACT:
SUBMITTER: Hemerly AS
PROVIDER: S-EPMC2653626 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20090201 5915
Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and centrosomes are normally duplicated once before cell division to maintain optimal genome integrity. We report a new role for the Orc1 protein, a subunit of the origin recognition complex (ORC) that is a key component of the DNA replication licensing machinery, in controlling centriole and centrosome copy number in human cells, independent of its role in DNA replication. ...[more]