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Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

ABSTRACT: OBJECTIVE:Brain-derived neurotrophic factor (BDNF) plays an important role in the survival, differentiation, and outgrowth of select peripheral and central neurons throughout adulthood. Growing evidence suggests that BDNF is involved in the pathophysiology of mood disorders. METHODS:Ten single nucleotide polymorphisms (SNPs) across the BDNF gene were genotyped in a sample of 1749 Caucasian Americans from 250 multiplex bipolar families. Family-based association analysis was used with three hierarchical bipolar disorder models to test for an association between SNPs in BDNF and the risk of bipolar disorder. In addition, an exploratory analysis was performed to test for an association of the SNPs in BDNF and the phenotypes of rapid cycling and episode frequency. RESULTS:Evidence of association (P<0.05) was found with several of the SNPs using multiple models of bipolar disorder; one of these SNPs also showed evidence of association (P<0.05) with rapid cycling. CONCLUSION:These results provide further evidence that variation in BDNF affects the risk for bipolar disorder.

SUBMITTER: Liu L

PROVIDER: S-EPMC2653694 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

Liu Lixiang L Foroud Tatiana T Xuei Xiaoling X Berrettini Wade W Byerley William W Coryell William W El-Mallakh Rif R Gershon Elliot S ES Kelsoe John R JR Lawson William B WB MacKinnon Dean F DF McInnis Melvin M McMahon Francis J FJ Murphy Dennis L DL Rice John J Scheftner William W Zandi Peter P PP Lohoff Falk W FW Niculescu Alexander B AB Meyer Eric T ET Edenberg Howard J HJ Nurnberger John I JI

Psychiatric genetics 20081201 6

<h4>Objective</h4>Brain-derived neurotrophic factor (BDNF) plays an important role in the survival, differentiation, and outgrowth of select peripheral and central neurons throughout adulthood. Growing evidence suggests that BDNF is involved in the pathophysiology of mood disorders.<h4>Methods</h4>Ten single nucleotide polymorphisms (SNPs) across the BDNF gene were genotyped in a sample of 1749 Caucasian Americans from 250 multiplex bipolar families. Family-based association analysis was used wi ...[more]

PMID: 19018231

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Project description:BackgroundThe brain-derived neurotrophic factor (BDNF) has been considered as an important candidate gene in bipolar disorder (BD); this association has been derived from several genetic and genome-wide studies. A polymorphic variant of the BDNF (Val66Met) confers some differences in the clinical presentation of affective disorders. In this study, we evaluated a sample population from Mexico City to determine whether the BDNF (rs6265) Val66Met polymorphism is associated with the body mass index (BMI) of patients with BD.MethodsThis association study included a sample population of 357 individuals recruited in Mexico City. A total of 139 participants were diagnosed with BD and 137 were classified as psychiatrically healthy controls (all individuals were interviewed and evaluated by the Diagnostic Interview for Genetic Studies). Genomic DNA was extracted from peripheral blood leukocytes. The quantitative polymerase chain reaction (qPCR) assay was performed in 96-well plates using the TaqMan Universal Thermal Cycling Protocol. After the PCR end point was reached, fluorescence intensity was measured in a 7,500 real-time PCR system and evaluated using the SDS v2.1 software, results were analyzed with Finetti and SPSS software. Concerning BMI stratification, random groups were defined as follows: normal <25 kg/m(2), overweight (Ow) =25.1-29.9 kg/m(2), and obesity (Ob) >30 kg/m(2).ResultsIn the present work, we report the association of a particular BMI phenotype with the presence of the Val66Met allele in patients with BD (P=0.0033 and odds ratio [95% confidence interval] =0.332 [157-0.703]), and correlated the risk for valine allele carriers with Ow and Ob in patients with BD.ConclusionWe found that the methionine allele confers a lower risk of developing Ow and Ob in patients with BD. We also confirmed that the G polymorphism represents a risk of developing Ow and Ob in patients with BD. In future studies, the haplotype analysis should provide additional evidence that BDNF may be associated with BD and BMI within the Mexican population.

Dataset Information

Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

Publications

Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

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