Ontology highlight
ABSTRACT:
SUBMITTER: Tobin JE
PROVIDER: S-EPMC2654275 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Tobin J E JE Latourelle J C JC Lew M F MF Klein C C Suchowersky O O Shill H A HA Golbe L I LI Mark M H MH Growdon J H JH Wooten G F GF Racette B A BA Perlmutter J S JS Watts R R Guttman M M Baker K B KB Goldwurm S S Pezzoli G G Singer C C Saint-Hilaire M H MH Hendricks A E AE Williamson S S Nagle M W MW Wilk J B JB Massood T T Laramie J M JM DeStefano A L AL Litvan I I Nicholson G G Corbett A A Isaacson S S Burn D J DJ Chinnery P F PF Pramstaller P P PP Sherman S S Al-hinti J J Drasby E E Nance M M Moller A T AT Ostergaard K K Roxburgh R R Snow B B Slevin J T JT Cambi F F Gusella J F JF Myers R H RH
Neurology 20080528 1
<h4>Background</h4>Microtubule-associated protein tau (MAPT) has been associated with several neurodegenerative disorders including forms of parkinsonism and Parkinson disease (PD). We evaluated the association of the MAPT region with PD in a large cohort of familial PD cases recruited by the GenePD Study. In addition, postmortem brain samples from patients with PD and neurologically normal controls were used to evaluate whether the expression of the 3-repeat and 4-repeat isoforms of MAPT, and n ...[more]