Ontology highlight
ABSTRACT:
SUBMITTER: Pascale E
PROVIDER: S-EPMC4826864 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Pascale Esterina E Di Battista Maria Elena ME Rubino Alfonso A Purcaro Carlo C Valente Marcella M Fattapposta Francesco F Ferraguti Giampiero G Meco Giuseppe G
Frontiers in cellular neuroscience 20160411
The microtubule-associated protein tau (MAPT) region has been conceptualized as a model of the interaction between genetics and functional disease outcomes in neurodegenerative disorders, such as Parkinson disease (PD). Indeed, haplotype-specific differences in expression and alternative splicing of MAPT transcripts affect cellular functions at different levels, increasing susceptibility to a range of neurodegenerative processes. In order to evaluate a possible link between MAPT variants, PD ris ...[more]