Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC2654547 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Liu Haiyan H Song Xianrang X Liu Chunxi C Xie Li L Wei Ling L Sun Ruopeng R
Journal of experimental & clinical cancer research : CR 20090215
<h4>Background</h4>Astrocyte elevated gene-1 (AEG-1) was originally characterized as a HIV-1-inducible gene in primary human fetal astrocyte. Recent studies highlight a potential role of AEG-1 in promoting tumor progression and metastasis. The aim of this study was to investigate if AEG-1 serves as a potential therapeutic target of human neuroblastoma.<h4>Methods</h4>We employed RNA interference to reduce AEG-1 expression in human neuroblastoma cell lines and analyzed their phenotypic changes.<h ...[more]