Ontology highlight
ABSTRACT:
SUBMITTER: Sollier J
PROVIDER: S-EPMC2655255 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Sollier Julie J Driscoll Robert R Castellucci Federica F Foiani Marco M Jackson Stephen P SP Branzei Dana D
Molecular biology of the cell 20090121 6
Recombination is important for DNA repair, but it can also contribute to genome rearrangements. RecQ helicases, including yeast Sgs1 and human BLM, safeguard genome integrity through their functions in DNA recombination. Sgs1 prevents the accumulation of Rad51-dependent sister chromatid junctions at damaged replication forks, and its functionality seems to be regulated by Ubc9- and Mms21-dependent sumoylation. We show that mutations in Smc5-6 and Esc2 also lead to an accumulation of recombinogen ...[more]