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ABSTRACT:
SUBMITTER: Kazimierczak KA
PROVIDER: S-EPMC2655462 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Kazimierczak Katarzyna A KA Scott Karen P KP Kelly Denise D Aminov Rustam I RI
Applied and environmental microbiology 20090123 6
The occurrence of genes conferring resistance to tetracyclines in the organic pig gut was assessed through the metagenomic approach. Of 9,000 bacterial artificial chromosome clones analyzed, 10 were identified as carrying the known tet(C), tet(W), and tet(40) genes, as well as novel genes encoding resistance to the tetracyclines minocycline and doxycycline. The latter are different from the known tet genes and are homologous to genes encoding UDP-glucose 4-epimerases, with the domain structure c ...[more]