Ontology highlight
ABSTRACT:
SUBMITTER: Bardaro MF
PROVIDER: S-EPMC2655691 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Bardaro Michael F MF Shajani Zahra Z Patora-Komisarska Krystyna K Robinson John A JA Varani Gabriele G
Nucleic acids research 20090112 5
The HIV-1 TAR RNA represents a well-known paradigm to study the role of dynamics and conformational change in RNA function. This regulatory RNA changes conformation in response to binding of Tat protein and of a variety of peptidic and small molecule ligands, indicating that its conformational flexibility and intrinsic dynamics play important roles in molecular recognition. We have used (13)C NMR relaxation experiments to examine changes in the motional landscape of HIV-1 TAR in the presence of ...[more]