Unknown

Dataset Information

0

Small molecule ligands for bulged RNA secondary structures.

ABSTRACT: A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.

SUBMITTER: Meyer ST 

PROVIDER: S-EPMC4975938 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Small molecule ligands for bulged RNA secondary structures.

Meyer S Todd ST   Hergenrother Paul J PJ  

Organic letters 20090901 18

A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay. ...[more]

Similar Datasets

Unknown Viral RNA Targets and Their Small Molecule Ligands
| S-EPMC7120917 | biostudies-literature
Unknown Small molecule recognition of disease-relevant RNA structures.
| S-EPMC7717589 | biostudies-literature
Unknown Small molecule targeting of RNA structures in neurological disorders.
| S-EPMC6785366 | biostudies-literature
Unknown Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.
| S-EPMC6589350 | biostudies-literature
Unknown Aptamer-enabled uptake of small molecule ligands.
| S-EPMC6200808 | biostudies-other
Unknown Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site.
| S-EPMC3537065 | biostudies-literature
Unknown Small-molecule ligands of methyl-lysine binding proteins.
| S-EPMC3109722 | biostudies-literature
Unknown Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions.
| S-EPMC3876275 | biostudies-literature
Unknown How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape.
| S-EPMC2655691 | biostudies-literature
Unknown Allostery at opioid receptors: modulation with small molecule ligands.
| S-EPMC6016636 | biostudies-literature