Ontology highlight
ABSTRACT:
SUBMITTER: Ma Q
PROVIDER: S-EPMC2655699 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Ma Qing Q Zhou Bin B Pu William T WT
Developmental biology 20080822 1
Isl1 and Nkx2-5-expressing cardiovascular progenitors play pivotal roles in cardiogenesis. Previously reported Cre-based fate-mapping studies showed that Isl1 progenitors contribute predominantly to the derivatives of the second heart field, and Nkx2-5 progenitors contributed mainly to the cardiomyocyte lineage. However, partial recombination of Cre reporter genes can complicate interpretation of Cre fate-mapping experiments. We found that a Gata4-based Cre-activated reporter was recombined by I ...[more]