Ontology highlight
ABSTRACT:
SUBMITTER: Krejci P
PROVIDER: S-EPMC2655766 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Cellular signalling 20081012 1
Activation of fibroblast growth factor receptor 3 (FGFR3) leads to attenuation of cartilage growth. The members of the STAT family of transcription factors are believed to participate in FGFR3 signaling in cartilage, however the molecular mechanism of this action is poorly understood. Here, we demonstrate that a chronic FGF stimulus leads to accumulation of STAT1, 3, 5 and 6, evident in both in vitro chondrocyte model and murine limb explant cultures. Despite the accumulation, both endogenous an ...[more]