Ontology highlight
ABSTRACT:
SUBMITTER: Yu EY
PROVIDER: S-EPMC2656765 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Yu Eun Young EY Wang Feng F Lei Ming M Lue Neal F NF
Nature structural & molecular biology 20080901 9
Ever shorter telomeres 3 (Est3) is an essential telomerase regulatory subunit thought to be unique to budding yeasts. Here we use multiple sequence alignment and hidden Markov model-hidden Markov model (HMM-HMM) comparison to uncover potential similarities between Est3 and the mammalian telomeric protein Tpp1. Analysis of site-specific mutants of Candida albicans Est3 revealed functional distinctions between residues that are conserved between Est3 and Tpp1 and those that are unique to Est3. Alt ...[more]