Unknown

Dataset Information

0

Preparation of bicyclic 1,2,4-trioxanes from gamma,delta-unsaturated ketones.


ABSTRACT: Treatment of gamma,delta-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

SUBMITTER: Ramirez AP 

PROVIDER: S-EPMC2657341 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Preparation of bicyclic 1,2,4-trioxanes from gamma,delta-unsaturated ketones.

Ramirez Armando P AP   Thomas Andrew M AM   Woerpel K A KA  

Organic letters 20090201 3


Treatment of gamma,delta-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation. ...[more]

Similar Datasets

| S-EPMC7901661 | biostudies-literature
| S-EPMC6824592 | biostudies-literature
| S-EPMC2733363 | biostudies-literature
| S-EPMC3596044 | biostudies-other
| S-EPMC2366803 | biostudies-literature
| S-EPMC2830285 | biostudies-literature
| S-EPMC6385668 | biostudies-other
| S-EPMC2652727 | biostudies-literature
| S-EPMC3065356 | biostudies-literature
| S-EPMC4304286 | biostudies-literature