Ontology highlight
ABSTRACT:
SUBMITTER: Motani A
PROVIDER: S-EPMC2658061 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090115 12
Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and its binding partner transthyretin. Analysis of the RBP4-A1120 co-crystal structure reveals that A1120 induces critical conformational changes at the RBP4-transthyretin interface. Administration of A1120 ...[more]