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Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease.


ABSTRACT: The interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity of angiographically proven CAD and determined its possible role in acute myocardial infarction (AMI).305 individuals with angiographically proven CAD (CAD-patients), were classified into 2 subgroups: 1) acute myocardial infarction (AMI, n?=?141), and 2) stable angina (SA, n?=?164). Ninety-one age- and sex-matched individuals without CAD, but with at least 2 classical cardiovascular risk factors, served as controls (non-CAD group). RBP4 serum levels were measured at hospital admission and were analyzed in relation to the coronary severity stenosis, assessed by the Gensini-score and the number of coronary narrowed vessels. Other clinical parameters, including insulin levels, HOMA-IR, hsCRP, glycaemic and lipid profile, and left-ventricular ejection fraction were also assessed.Serum RBP4 levels were significantly elevated in patients with CAD compared to non-CAD patients (39.29?±?11.72 mg/L vs. 24.83?±?11.27 mg/L, p?

SUBMITTER: Lambadiari V 

PROVIDER: S-EPMC4156962 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease.

Lambadiari Vaia V   Kadoglou Nikolaos P E NP   Stasinos Vassilios V   Maratou Eirini E   Antoniadis Aias A   Kolokathis Fotios F   Parissis John J   Hatziagelaki Erifili E   Iliodromitis Efstathios K EK   Dimitriadis George G  

Cardiovascular diabetology 20140821


<h4>Background</h4>The interplay between the novel adipokine retinol-binding protein-4 (RBP4) and coronary artery disease (CAD) is still obscure. We investigated the relationship between RBP4 levels and the presence and severity of angiographically proven CAD and determined its possible role in acute myocardial infarction (AMI).<h4>Methods</h4>305 individuals with angiographically proven CAD (CAD-patients), were classified into 2 subgroups: 1) acute myocardial infarction (AMI, n = 141), and 2) s  ...[more]

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