Ontology highlight
ABSTRACT:
SUBMITTER: Ji H
PROVIDER: S-EPMC2658647 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Ji Haitao H Tan Sidhartha S Igarashi Jotaro J Li Huiying H Derrick Matthew M Martásek Pavel P Roman Linda J LJ Vásquez-Vivar Jeannette J Poulos Thomas L TL Silverman Richard B RB
Annals of neurology 20090201 2
<h4>Objective</h4>To design a new class of selective neuronal nitric oxide synthase (NOS) inhibitors, and demonstrate that administration in a rabbit model for cerebral palsy (CP) prevents hypoxia-ischemia-induced deaths and reduces the number of newborn kits exhibiting signs of CP.<h4>Methods</h4>We used a novel computer-based drug design method called fragment hopping to identify new chemical entities, synthesized them, and conducted in vitro enzyme inhibition studies with the three isozymes o ...[more]