Ontology highlight
ABSTRACT:
SUBMITTER: Lawton GR
PROVIDER: S-EPMC2775099 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Lawton Graham R GR Ralay Ranaivo Hantamalala H Chico Laura K LK Ji Haitao H Xue Fengtian F Martásek Pavel P Roman Linda J LJ Watterson D Martin DM Silverman Richard B RB
Bioorganic & medicinal chemistry 20090214 6
Overproduction of nitric oxide by neuronal nitric oxide synthase (nNOS) has been linked to several neurodegenerative diseases. We have recently designed potent and isoform selective inhibitors of nNOS, but the lead compound contains several basic functional groups. A large number of charges and hydrogen bond donors can impede the ability of molecules to cross the blood brain barrier and thereby limit the effectiveness of potential neurological therapeutics. Replacement of secondary amines in our ...[more]