Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
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ABSTRACT:
SUBMITTER: Yeh JR
PROVIDER: S-EPMC2658727 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.
Yeh Jing-Ruey J JR Munson Kathleen M KM Elagib Kamaleldin E KE Goldfarb Adam N AN Sweetser David A DA Peterson Randall T RT
Nature chemical biology 20090126 4
It has been proposed that inhibitors of an oncogene's effects on multipotent hematopoietic progenitor cell differentiation may change the properties of the leukemic stem cells and complement the clinical use of cytotoxic drugs. Using zebrafish, we developed a robust in vivo hematopoietic differentiation assay that reflects the activity of the oncogene AML1-ETO. Screening for modifiers of AML1-ETO-mediated hematopoietic dysregulation uncovered unexpected roles of COX-2- and beta-catenin-dependent ...[more]
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