Ontology highlight
ABSTRACT:
SUBMITTER: Graziani I
PROVIDER: S-EPMC2659352 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Graziani Irene I Doyle Andrew A Sterling Sarah S Kirov Alek A Tarantini Francesca F Landriscina Matteo M Kumar Thallapuranam Krishnaswamy S TK Neivandt David D Prudovsky Igor I
Biochemical and biophysical research communications 20090220 3
Newly synthesized proteins are usually exported through the endoplasmic reticulum (ER) and Golgi due to the presence in their primary sequence of a hydrophobic signal peptide that is recognized by the ER translocation system. However, some secreted proteins lack a signal peptide and are exported independently of ER-Golgi. Fibroblast growth factor (FGF)1 is included in this group of polypeptides, as well as S100A13 that is a small calcium-binding protein critical for FGF1 export. Classically secr ...[more]