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ABSTRACT:
SUBMITTER: DeAngelis A
PROVIDER: S-EPMC2659807 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20090101 3
Conditions are described for the Rh-catalyzed formation of highly functionalized dihydro- and tetrahydrofuran products via three-component reactions of aldehydes, alpha-alkyl-alpha-diazoesters, and dipolarophiles. The alkyl-substituted carbonyl ylides that are generated in this fashion are highly reactive in cycloaddition reactions and display a scope of reactivity that is much broader than the three-component reactions of carbonyl ylides derived from ethyl diazoacetate or alpha-aryl-alpha-diazo ...[more]