Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC3721980 | biostudies-literature | 2010 Jan-Feb
REPOSITORIES: biostudies-literature
Wang Kan K Kim Dabin D Dömling Alexander A
Journal of combinatorial chemistry 20100101 1
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Here we describe valuable general protocols for the synthesis of arrays of 2-aminothiophene-3-carboxamides from cyanoacetamides, aldehydes or ketones, and sulfur via a Gewald-3CR variation. In many cases the reactions involve a very convenient work up by simple precipitation in water and filtration. More than 40 new products are described. We foresee our protocol and the resulting d ...[more]