Ontology highlight
ABSTRACT:
SUBMITTER: Bogen O
PROVIDER: S-EPMC2660608 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Bogen Oliver O Joseph Elizabeth K EK Chen Xiaojie X Levine Jon D JD
The European journal of neuroscience 20080628 1
The function of the isolectin B4 (IB4+)-binding and GDNF-dependent Ret (Ret+)-expressing non-peptidergic subpopulation of nociceptors remain poorly understood. We demonstrate that acute administration of GDNF sensitizes nociceptors and produces mechanical hyperalgesia in the rat. Intrathecal IB4-saporin, a selective toxin for IB4+/Ret+-nociceptors, attenuates GDNF but not NGF hyperalgesia. Conversely, intrathecal antisense to Trk A attenuated NGF but not GDNF hyperalgesia. Intrathecal administra ...[more]