Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5970202 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Li Yang Y Xi Zhichao Z Chen Xiaoqiong X Cai Shuangfan S Liang Chen C Wang Zhen Z Li Yingyi Y Tan Hongsheng H Lao Yuanzhi Y Xu Hongxi H
Cell death & disease 20180501 5
Gemcitabine (GEM)-induced drug resistance is the major reason for the failure of chemotherapy in pancreatic cancer (PC). In this study, we found that Oblongifolin C (OC) efficiently inhibited PC cell proliferation by inducing G0/G1 arrest and apoptosis. Also, our mechanism study demonstrated that OC re-sensitized the GEM-resistant PC cells through the ubiquitin-proteasome-dependent degradation of Src, and then downregulating the MAPK pathway. Knockdown of Src plus OC resulted in a greater inhibi ...[more]