Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC2661613 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Yang Zhihong Z MacQuarrie Kyle L KL Analau Erwin E Tyler Ashlee E AE Dilworth F Jeffery FJ Cao Yi Y Diede Scott J SJ Tapscott Stephen J SJ
Genes & development 20090301 6
Rhabdomyosarcomas are characterized by expression of myogenic specification genes, such as MyoD and/or Myf5, and some muscle structural genes in a population of cells that continues to replicate. Because MyoD is sufficient to induce terminal differentiation in a variety of cell types, we have sought to determine the molecular mechanisms that prevent MyoD activity in human embryonal rhabdomyosarcoma cells. In this study, we show that a combination of inhibitory Musculin:E-protein complexes and a ...[more]