Ontology highlight
ABSTRACT:
SUBMITTER: Revert F
PROVIDER: S-EPMC2662082 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Revert Fernando F Ventura Ignacio I Martínez-Martínez Pilar P Granero-Moltó Froilán F Revert-Ros Francisco F Macías Jesús J Saus Juan J
The Journal of biological chemistry 20080904 44
Goodpasture-antigen binding protein (GPBP) is a nonconventional Ser/Thr kinase for basement membrane type IV collagen. Various studies have questioned these findings and proposed that GPBP serves as transporter of ceramide between the endoplasmic reticulum and the Golgi apparatus. Here we show that cells expressed at least two GPBP isoforms resulting from canonical (77-kDa) and noncanonical (91-kDa) mRNA translation initiation. The 77-kDa polypeptide interacted with type IV collagen and localize ...[more]