Ontology highlight
ABSTRACT:
SUBMITTER: Okazaki H
PROVIDER: S-EPMC2662263 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Okazaki Hiroaki H Igarashi Masaki M Nishi Makiko M Sekiya Motohiro M Tajima Makiko M Takase Satoru S Takanashi Mikio M Ohta Keisuke K Tamura Yoshiaki Y Okazaki Sachiko S Yahagi Naoya N Ohashi Ken K Amemiya-Kudo Michiyo M Nakagawa Yoshimi Y Nagai Ryozo R Kadowaki Takashi T Osuga Jun-ichi J Ishibashi Shun S
The Journal of biological chemistry 20080909 48
Unstable lipid-rich plaques in atherosclerosis are characterized by the accumulation of macrophage foam cells loaded with cholesterol ester (CE). Although hormone-sensitive lipase and cholesteryl ester hydrolase (CEH) have been proposed to mediate the hydrolysis of CE in macrophages, circumstantial evidence suggests the presence of other enzymes with neutral cholesterol ester hydrolase (nCEH) activity. Here we show that the murine orthologue of KIAA1363, designated as neutral cholesterol ester h ...[more]