Ontology highlight
ABSTRACT:
SUBMITTER: Parathath S
PROVIDER: S-EPMC3220591 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110920 46
Although esterification of free cholesterol to cholesteryl ester in the liver is known to be catalyzed by the enzyme acyl-coenzyme A:cholesterol acyltransferase, ACAT, the neutral cholesteryl ester hydrolase (nCEH) that catalyzes the reverse reaction has remained elusive. Because cholesterol undergoes continuous cycling between free and esterified forms, the steady-state concentrations in the liver of the two species and their metabolic availability for pathways, such as lipoprotein assembly and ...[more]