Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC2662446 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Song Xuezheng X Xia Baoyun B Stowell Sean R SR Lasanajak Yi Y Smith David F DF Cummings Richard D RD
Chemistry & biology 20090101 1
Galectin-1 (Gal-1) and galectin-3 (Gal-3) are widely expressed galectins with immunoregulatory functions in animals. To explore their glycan specificity, we developed microarrays of naturally occurring glycans using a bifunctional fluorescent linker, 2-amino-N-(2-aminoethyl)-benzamide (AEAB), directly conjugated through its arylamine group by reductive amination to free glycans to form glycan-AEABs (GAEABs). Glycans from natural sources were used to prepare over 200 GAEABs, which were purified b ...[more]