Ontology highlight
ABSTRACT:
SUBMITTER: Noll AJ
PROVIDER: S-EPMC4847615 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Noll Alexander J AJ Gourdine Jean-Philippe JP Yu Ying Y Lasanajak Yi Y Smith David F DF Cummings Richard D RD
Glycobiology 20160107 6
The biological recognition of human milk glycans (HMGs) is poorly understood. Because HMGs are rich in galactose we explored whether they might interact with human galectins, which bind galactose-containing glycans and are highly expressed in epithelial cells and other cell types. We screened a number of human galectins for their binding to HMGs on a shotgun glycan microarray consisting of 247 HMGs derived from human milk, as well as to a defined HMG microarray. Recombinant human galectins (hGal ...[more]