Ontology highlight
ABSTRACT:
SUBMITTER: Piening BD
PROVIDER: S-EPMC2662705 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Piening Brian D BD Wang Pei P Subramanian Aravind A Paulovich Amanda G AG
Radiation research 20090201 2
Activation of the DNA damage response pathway is a hallmark for early tumorigenesis, while loss of pathway activity is associated with disease progression. Thus we hypothesized that a gene expression signature associated with the DNA damage response may serve as a prognostic signature for outcome in cancer patients. We identified ionizing radiation-responsive transcripts in human lymphoblast cells derived from 12 individuals and used this signature to screen a panel of cancer data sets for the a ...[more]