Proteomics

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Oncogene-Mediated Metabolic Gene Signature Predicts Breast Cancer Outcome

ABSTRACT: We performed shotgun protoemic analysis of tumor samples from HCC1806 shCtrl and shTrop2 xenograft mice.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)

TISSUE(S): Breast Cancer Cell Line

SUBMITTER: Sharon Pitteri  

LAB HEAD: Sharon Pitteri

PROVIDER: PXD028335 | Pride | 2021-12-19

REPOSITORIES: Pride

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Dataset's files

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Action DRS
AA5_082319_01.raw Raw
AA5_082319_01.raw_20190829_Byonic_human_database.xlsx Xlsx
AA5_082319_01.raw_20190904_Byonic_mouse_database.xlsx Xlsx
AA5_082319_02.raw Raw
AA5_082319_02.raw_20190829_Byonic_human_database.xlsx Xlsx
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Publications

Breast cancer remains the second most lethal cancer among women in the United States and triple-negative breast cancer is the most aggressive subtype with limited treatment options. Trop2, a cell membrane glycoprotein, is overexpressed in almost all epithelial cancers. In this study, we demonstrate that Trop2 is overexpressed in triple-negative breast cancer (TNBC), and downregulation of Trop2 delays TNBC cell and tumor growth supporting the oncogenic role of Trop2 in breast cancer. Through prot  ...[more]

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