Evidence for antisense transcription associated with microRNA target mRNAs in Arabidopsis.

ABSTRACT: Antisense transcription is a pervasive phenomenon, but its source and functional significance is largely unknown. We took an expression-based approach to explore microRNA (miRNA)-related antisense transcription by computational analyses of published whole-genome tiling microarray transcriptome and deep sequencing small RNA (smRNA) data. Statistical support for greater abundance of antisense transcription signatures and smRNAs was observed for miRNA targets than for paralogous genes with no miRNA cleavage site. Antisense smRNAs were also found associated with MIRNA genes. This suggests that miRNA-associated "transitivity" (production of small interfering RNAs through antisense transcription) is more common than previously reported. High-resolution (3 nt) custom tiling microarray transcripto

SUBMITTER: Luo QJ 

PROVIDER: S-EPMC2664332 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature