Ontology highlight
ABSTRACT:
SUBMITTER: Sun Q
PROVIDER: S-EPMC5144995 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Sun Qianwen Q Csorba Tibor T Skourti-Stathaki Konstantina K Proudfoot Nicholas J NJ Dean Caroline C
Science (New York, N.Y.) 20130501 6132
Roles for long noncoding RNAs (lncRNAs) in gene expression are emerging, but regulation of the lncRNA itself is poorly understood. We have identified a homeodomain protein, AtNDX, that regulates COOLAIR, a set of antisense transcripts originating from the 3' end of Arabidopsis FLOWERING LOCUS C (FLC). AtNDX associates with single-stranded DNA rather than double-stranded DNA non-sequence-specifically in vitro, and localizes to a heterochromatic region in the COOLAIR promoter in vivo. Single-stran ...[more]