Ontology highlight
ABSTRACT:
SUBMITTER: Taylor CM
PROVIDER: S-EPMC2664537 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Taylor Christina M CM Barda Yaniv Y Kisselev Oleg G OG Marshall Garland R GR
Journal of medicinal chemistry 20080816 17
Modulation of interactions between activated GPCRs (G-protein coupled receptors) and the intracellular (IC) signal transducers, heterotrimeric G-proteins, is an attractive, yet essentially unexplored, paradigm for treatment of certain diseases. Regulating downstream signaling for treatment of congenital diseases due to constitutively active GPCRs, as well as tumors where GPCRs are often overexpressed, requires the development of new methodologies. Modeling, experimental data, docking, scoring, a ...[more]