Dataset Information
Recent advances in structure-based virtual screening of G-protein coupled receptors.
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ABSTRACT:
SUBMITTER: Ananthan S
PROVIDER: S-EPMC2664893 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Recent advances in structure-based virtual screening of G-protein coupled receptors.
The AAPS journal 20090317 1
In addition to the rhodopsin crystal structure, high-resolution crystal structures of ligand-mediated G-protein-coupled receptors (GPCRs) have recently become available, and these have become attractive templates for developing homology models of several GPCRs of therapeutic interest. These crystal structures and the homology models derived from them have provided significant insights into ligand-receptor interactions. Moreover, several studies have demonstrated that the structural models are in ...[more]