Ontology highlight
ABSTRACT:
SUBMITTER: Neaves KJ
PROVIDER: S-EPMC2665228 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Neaves Kelly J KJ Cooper Laurie P LP White John H JH Carnally Stewart M SM Dryden David T F DT Edwardson J Michael JM Henderson Robert M RM
Nucleic acids research 20090217 6
Atomic force microscopy (AFM) allows the study of single protein-DNA interactions such as those observed with the Type I Restriction-Modification systems. The mechanisms employed by these systems are complicated and understanding them has proved problematic. It has been known for years that these enzymes translocate DNA during the restriction reaction, but more recent AFM work suggested that the archetypal EcoKI protein went through an additional dimerization stage before the onset of translocat ...[more]