Ontology highlight
ABSTRACT:
SUBMITTER: Herrero-Martin G
PROVIDER: S-EPMC2666037 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Herrero-Martín Griselda G Høyer-Hansen Maria M García-García Celina C Fumarola Claudia C Farkas Thomas T López-Rivas Abelardo A Jäättelä Marja M
The EMBO journal 20090205 6
The capacity of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) to trigger apoptosis preferentially in cancer cells, although sparing normal cells, has motivated clinical development of TRAIL receptor agonists as anti-cancer therapeutics. The molecular mechanisms responsible for the differential TRAIL sensitivity of normal and cancer cells are, however, poorly understood. Here, we show a novel signalling pathway that activates cytoprotective autophagy in untransformed human epit ...[more]