Ontology highlight
ABSTRACT:
SUBMITTER: Sawallisch C
PROVIDER: S-EPMC2666575 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Sawallisch Corinna C Berhörster Kerstin K Disanza Andrea A Mantoani Sara S Kintscher Michael M Stoenica Luminita L Dityatev Alexander A Sieber Sabrina S Kindler Stefan S Morellini Fabio F Schweizer Michaela M Boeckers Tobias M TM Korte Martin M Scita Giorgio G Kreienkamp Hans-Jürgen HJ
The Journal of biological chemistry 20090210 14
IRSp53 is an essential intermediate between the activation of Rac and Cdc42 GTPases and the formation of cellular protrusions; it affects cell shape by coupling membrane-deforming activity with the actin cytoskeleton. IRSp53 is highly expressed in neurons where it is also an abundant component of the postsynaptic density (PSD). Here we analyze the physiological function of this protein in the mouse brain by generating IRSp53-deficient mice. Neurons in the hippocampus of young and adult knock-out ...[more]